Skin immunity is regulated by many mediator molecules.One is the neuropeptide calcitonin gene-related Tent Accessories peptide (CGRP).CGRP has roles in regulating the function of components of the immune system including T cells, B cells, dendritic cells (DCs), Books endothelial cells (ECs), and mast cells (MCs).Herein we discuss actions of CGRP in mediating inflammatory and vascular effects in various cutaneous models and disorders.